1. Background: Biology, Physiology and Pharmacology.- Introduction and Overview of the Hematopoietic Growth Factors.- Early Acting Hematopoietic Growth Factors.- Growth Factor Receptors and Signal Transduction.- The RANKL Axis andOsteoclastogenesis and Activiation.- Granulocyte Colony-Stimulating Factors.- Erythropoietic-Stimulating Agents.- Thrombopoietin Factors.- 2. The Myeloid Growth Factors.- Neutropenia and Febrile Neutropenia in Patients with Cancer.- Cyclic and Chronic Neutropenia.- Early Clinical Trials of the Recombinant Myeloid Growth Factors.-Randomized Controlled Clinical Trials of the Myeloid Growth Factors.- Meta-analyses of Randomized Controlled Trials.- Clinical Practice Guidelines for the Use of Hematopoietic Cology-Stimulating Factors: ASCO, EORTC, NCCN.- Safety Considerations and the Myeloid Growth Factors.- Index.
EAN/ISBN : 9781441970732
Publisher(s): Springer, Berlin, Springer Science & Business Media
Discussed keywords: Hämatopoese, Onkologie
Format: ePub/PDF

Author(s): Lyman, Gary H. - Dale, David C.