DNA as the genetic material is a topic of intense interest in the 21st century, with the genomes of many organisms having been sequenced. The double helix structure discovered by Watson and Crick 50 years ago is now very familiar and its importance for DNA function is widely appreciated.

However, it has become clear that there are many deviations from this basic structure that have important biological consequences. Prominent among these are the 'topological' configurations: supercoiling, knotting, and catenation (linking).

Unfortunately, a full understanding of these features of DNA structure requires the grasp of concepts that can prove difficult for both students and more advanced researchers. This book aims to explain these ideas simply, but rigorously, to allow a wider appreciation of DNA topology.

"DNA Topology" starts with a basic account of DNA structure before going on to cover DNA supercoiling, the definitions and physical meanings of linking number, twist, and writhe.

Publisher: Oxford University Press; 2 edition (April 14, 2005)
Language: English
ISBN-10: 019856709X
ISBN-13: 978-0198567097