Tik-Tok of Oz follows a band of characters as they attempt to find and rescue The Shaggy Man's brother from the Nome King. Some we have met before, such as The Shaggy Man, the Nome King, Polychrome, Tik-Tok, and even a brief appearance by Toto (who has a surprise for everyone). Many interesting new characters also make an appearance, including Queen Ann Soforth of Oogaboo, who wants to conquer Oz; Betsy Bobbin and her mule Hank, who wash ashore in Oz during a storm; the Rose Princess Ozga; and a lackadaisical, flying dragon named Quox.