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LONGEVITY EXPERIMENTAL PROTOYPE COLLECTION
DETAILED DESCRIPTION OF TRACKS BELOW;
Collection of 15 files
retail ; $749.55
· SIRTIN6
· DELPHINDIN
· FOLLISTATIN
· IRISIN
· UROLITHIN A - Known commercially as Mitopure
· PGC1A
· Cycloastragenol
· CYANIDIN
This collection contains the following products:
DELPHINIDIN CYANDIN LOW COIL .mp3
DELPHINIDIN CYANIDIN HI FREQ SOUND.mp3
IRISIN HI FREQ SOUND.mp3
IRISIN COIL TRACK.mp3
IRISIN LOW COIL .mp3
IRISIN LOW.wav
Urolithin A HI FREQ SOUND VERSION.mp3
Urolithin A HIGH FREQ.mp3
Urolithin A LOW COIL .mp3
Urolithin A LOW.wav
PGC 1A HI FREQ SOUND.mp3
PGC 1A COIL TRACK.mp3
PGC1A LOW COIL .mp3
PGC1A LOW.wav
SIRTIN 6 LOW COIL.mp3
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DESCRIPTION ;
What is the GREY sticky mucus in your kidneys?
DELPHINDIN Cyandin directly effects natal Qi ( Jing . Chi ) by dissolving the grey mucus film that collects over the surface of kindeys due to aging.
Sodium_Glucose_Cotransport_2 Protein, which is a substance that clogs up the tubes in our kidneys, preventing - or at least limiting - the discharge of excess sugars with our urine.
This could be a factor in the inability to clear the gunk from our brains.
Sticky, Grey Protein is Preventing your Kidneys from Draining Blood Sugar ... Some of us struggle with blood sugar issues because we have a sticky ...
SG2 is a sticky protein that forms grey mucus over the kidneys, especially in older people. It determines the quantity of sugar that gets drained from your kidneys. High levels impair the functionality of kidneys to lower blood sugar. It is essential to know that some individuals have naturally higher levels of SG2
Delphinidin, which keeps your Blood Sugar Drain on point even if you age.
Supplementation with cyanidin and delphinidin mitigates high fat diet-induced endotoxemia and associated liver inflammation in mice
helps your kidneys flush out unneeded sugar, regardless of age.
Delphinidin, a member of the anthocyanin family, inhibits glucose absorption, increases glucagon-like peptide-1 (GLP-1) secretion, and improves insulin secretion in diabetes. However, whether delphinidin plays a protective role in pancreatic β-cell mass and function is not clear.
Delphinidin is a natural compound found in many fruits and vegetables, particularly berries, and is recognized for its potent antioxidant, anti-inflammatory, and potential anti-cancer properties; it may be beneficial for protecting against skin damage from UV radiation, promoting cardiovascular health, and potentially helping manage conditions like diabetes and obesity due to its ability to regulate blood sugar and fat metabolism.
Key potential benefits of Delphinidin include:
Antioxidant activity:
Helps combat oxidative stress in the body by neutralizing free radicals, potentially protecting against cell damage and chronic diseases.
Anti-inflammatory effects:
May help reduce inflammation by inhibiting the production of inflammatory molecules like COX-2.
Skin protection:
Research suggests delphinidin could protect skin cells from UV-induced damage and contribute to maintaining healthy skin aging.
Cardiovascular health:
May improve endothelial function, reduce platelet aggregation, and potentially lower the risk of cardiovascular diseases.
Anti-cancer potential:
Studies indicate delphinidin might have anti-proliferative effects on cancer cells and may help inhibit tumor growth.
Metabolic benefits:
Some research suggests delphinidin could play a role in regulating blood sugar levels and potentially aid in managing diabetes.
Where to find Delphinidin:
Berries: Blueberries, blackberries, raspberries, cranberries
Purple fruits: Purple grapes, plums, eggplants
Red vegetables: Red cabbage, beetroot
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PGC1A, also known as peroxisome proliferator-activated receptor coactivator-1 alpha, is a protein crucial for regulating cellular energy metabolism, primarily by promoting mitochondrial biogenesis (creation of new mitochondria) which is vital for generating energy within cells; essentially, it helps cells produce more energy when needed through increased mitochondrial function, making it beneficial for maintaining overall metabolic health and preventing conditions like muscle atrophy, heart failure, and neurodegeneration.
Key functions of PGC1A:
Muscle function:
Increases muscle fiber type switching, enhancing exercise capacity and insulin sensitivity in skeletal muscle.
Thermogenesis:
Regulates brown fat activity, which is critical for burning calories to generate heat in response to cold exposure.
Cellular stress response:
Protects cells against oxidative damage by regulating antioxidant genes.
Metabolic adaptations:
Helps the body adapt to changes in energy needs, like fasting or exercise, by regulating gene expression related to glucose and fatty acid metabolism.
Important points to remember about PGC1A:
Exercise and PGC1A:
Physical activity significantly increases PGC1A expression, contributing to the beneficial effects of exercise on muscle health and metabolism.
Disease implications:
Low PGC1A levels have been linked to various diseases including type 2 diabetes, obesity, neurodegenerative disorders like Parkinsons disease, and heart failure.
Regulation:
PGC1A activity is influenced by various factors like hormones, nutritional status, and cellular energy levels.
Urolithin A is primarily considered beneficial for improving muscle function, particularly in older adults, by stimulating a process called mitophagy which helps maintain healthy mitochondria within muscle cells, potentially leading to increased muscle strength and endurance with exercise; it is derived from food sources like pomegranates, walnuts, and berries through gut bacteria metabolism and may also have potential anti-inflammatory and antioxidant properties.
Key points about Urolithin A:
Muscle health:
The primary benefit of Urolithin A is its ability to enhance muscle function by promoting the removal of damaged mitochondria (mitophagy), which can improve exercise performance and potentially mitigate age-related muscle decline.
Source:
Urolithin A is not directly found in food but is produced by gut bacteria when they break down ellagic acid found in certain fruits like pomegranates and berries.
Potential benefits beyond muscle health:
Research suggests Urolithin A may also have anti-inflammatory effects, potentially beneficial for conditions related to inflammation, and could potentially play a role in cognitive function due to its impact on mitochondrial health in brain cells.
Follistatin is an incredible muscle, mass promoter. The FST gene codes for the follistatin protein, a signaling protein involved in muscle growth. When delivered via intranasal injection, FST extends the lifespan of mice by about 30 and improves their physical performance and coordination
Follistatin is primarily considered beneficial for promoting muscle growth and enhancing muscle healing after injury or disease by inhibiting the activity of myostatin, a protein that restricts muscle mass; this makes it a potential therapeutic target for conditions like muscular dystrophy and age-related muscle wasting (sarcopenia).
Key points about follistatin:
Muscle building:
Its primary function is to increase muscle mass and strength by blocking myostatin, leading to muscle hypertrophy.
Muscle regeneration:
Follistatin can improve muscle healing after injury by stimulating muscle cell regeneration and angiogenesis (new blood vessel formation).
Potential therapeutic applications:
Due to its muscle-building properties, research is exploring follistatin as a treatment for muscle wasting diseases like Duchenne muscular dystrophy and sarcopenia.
Important considerations:
Banned in sports:
As follistatin can significantly enhance muscle mass, it is considered a performance-enhancing drug and is banned by most sports organizations.
Limited clinical trials:
While research shows promise, more clinical trials are needed to fully understand the safety and efficacy of follistatin in humans
Sirtuin 6 (SIRT6) is a protein primarily recognized for its role in maintaining genomic stability, DNA repair, and regulating aging by impacting cellular processes like metabolism and inflammation, potentially contributing to longevity by protecting against age-related diseases through its influence on chromatin structure and gene expression; essentially, it is considered beneficial for promoting healthy aging and potentially preventing certain diseases associated with aging.
Key points about SIRT6:
DNA repair:
SIRT6 plays a crucial role in DNA double-strand break repair by stabilizing repair proteins at the damage site, contributing to genomic stability.
Telomere maintenance:
Research suggests SIRT6 might be involved in maintaining telomere length, which is associated with cellular aging.
Metabolic regulation:
SIRT6 can influence metabolic processes by regulating gene expression related to glucose metabolism and fat storage.
Anti-inflammatory effects:
Studies indicate SIRT6 may have anti-inflammatory properties by modulating the expression of inflammatory cytokines.
Cancer potential:
While SIRT6 can act as a tumor suppressor in some contexts, its role in cancer is complex and depends on the specific cancer type and cellular environment.
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Cycloastragenol, Lengthening Telomeres with Astragalus,
people who used this supplement reported that they noticed
improvement in their skin and immune system function. Over
50 percent saw an improvement in vision, libido, and quality
of sleep. said to increase overall telomere length.
Cycloastragenol is primarily considered beneficial for its potential anti-aging effects, primarily due to its ability to activate telomerase, an enzyme that helps maintain telomere length, which is associated with cellular aging; research suggests it may also possess anti-inflammatory, antioxidant, and liver protective properties, potentially aiding in overall health and longevity.
Key potential benefits of Cycloastragenol:
Telomere elongation: By activating telomerase, cycloastragenol may help lengthen telomeres, which are protective caps at the end of chromosomes that shorten with age.
Anti-aging effects: Due to its telomerase activating properties, cycloastragenol is studied for its potential to slow down the aging process.
Anti-inflammatory activity: Studies indicate cycloastragenol may have anti-inflammatory properties, potentially helping to reduce inflammation in the body.
Liver protection: Some research suggests cycloastragenol may protect the liver from damage.
Endothelial protection: Cycloastragenol may also help protect the lining of blood vessels
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PGC-1alpha stimulates mitochondrial biogenesis and promotes the remodeling of muscle tissue to a fiber-type composition that is metabolically more oxidative and less glycolytic in nature, and it participates in the regulation of both carbohydrate and lipid metabolism. It is strongly induced by cold exposure, linking this environmental stimulus to adaptive thermogenesis. It is highly likely that PGC-1alpha is intimately involved in disorders such as obesity, diabetes, and cardiomyopathy. In particular, its regulatory function in lipid metabolism makes it an inviting target for pharmacological intervention in the treatment of obesity and Type 2 diabetes.
What does irisin do in the body?
Irisin is a hormone that has the ability to activate beneficial changes in adipose tissue that improve muscle activity; therefore, moderate increases in irisin produce an improvement in insulin resistance induced by a diet [8].
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Irisin promotes brown fat cell growth
Irisin is a protein produced by muscles during exercise, primarily recognized for its potential to promote browning of white adipose tissue, essentially converting it into calorie-burning brown fat, which could contribute to improved metabolic health by increasing energy expenditure and potentially aiding in weight management; it may also have beneficial effects on glucose metabolism, cognitive function, and inflammation reduction, although further research is needed to fully understand its role in humans.
Key points about irisin:
Exercise-induced:
Irisin is primarily produced in response to physical activity, particularly endurance exercise, making it often referred to as an exercise hormone.
Brown fat activation:
The main function of irisin is believed to be the transformation of white adipose tissue into brown adipose tissue, which burns more calories to generate heat.
Potential metabolic benefits:
This browning effect could contribute to improved insulin sensitivity, better blood sugar control, and potentially help manage obesity.
Cognitive function:
Some studies suggest irisin may play a role in cognitive health by protecting against neuroinflammation and potentially improving cognitive function
Subject: Health benefits of Irisin:
Health benefits of Irisin:
1. Balances Blood Sugar And Fights Diabetes
Irisin improves blood sugar regulation. It increases glucose tolerance and reduces
insulin resistance.
Irisin signals via AMP-activated kinase (AMPK) pathway to mediate glucose uptake and
fatty acid oxidation. It also lowers hemoglobin A1c.
Irisin may also play an important role in the regulation of maternalfetal glucose
homeostasis. Low levels of irisin is associated with impaired carbohydrate metabolism
in infants.
In animal models with Type 1 Diabetes, irisin helped repair cells.
2. Improves Weight Loss
Irisin improves weight loss by inducing PGC1a.
PGC1a is induced in muscle by exercise and stimulates many of the best known
beneficial effects of exercise in muscle: mitochondrial biogenesis, angiogenesis and
fiber-type switching.
PGC1a induces FNDC5. FNDC5 is the precursor of irisin.
FNDC5 promotes the conversion of white fat to brown fat (thermogenesis via PPARa).
FNDC5 influneces UCP1, which also contributes to the browning of white fat.
Brown fat has more mitochondria than white fat, so it is able to burn faster and give
you more energy.
Irisin can also decrease food intake.
When rats were injected with irisin into the hypotalamus, they ate less.
3. Supports The Skeletal System
In mice, irisin released from skeletal muscle during exercise acts directly on bone
by increasing cortical bone mineral density, bone perimeter and polar moment of
inertia.
It may promote bone formation so that bones can better adapt to the increased load
during persistent exercise.
It can do it without browning response of adipose tissue when given at a lower dose.
It may help with osteoperosis.
It also provides resistance to muscular dystrophy and denervation-linked muscular
atrophy.
Irisin has also been shown to be positively correlated with bone mineral density in
adolescent women.
4. Is Anti-Aging
Irisin legnthens telomeres. Telomere shortening is a genetic marker of aging.
Irisin also decreases with age. Increasing irisin may therefore decrease aging.
5. Has Anti-Cancer Effects
Irisin expression may help hepatic cancer. It has also shown to protect normal cells
and create apoptosis (cell death by 22-fold) in cancer cells.
Irisin levels are lower in hepatic and breast cancers, suggesting a possible
protective role.
6. Protects The Heart, Brain and Vascular System
A mouse study showed that irisin might have a preventive role in atherosclerosis.
Administration of irisin protected against endothelial injury and ameliorated
atherosclerosis by inhibition of oxidative stress.
Also, irisin decreased the plaque area and the infiltrating macrophages and T
lymphocytes in the plaques, and down-regulated the mRNA expression of inflammatory
cytokines in the aortas.
Higher irisin levels may contribute lower total cholesterol in both men and women.
It also decreases the oxidative stress from LDL cholesterol.
In rats with hypertension, irisin was able to lower blood pressure by increasing
nitric oxide (via AMPK-Akt-eNOS- NO Pathway).
HDAC4 overexpression can induce cell death, increase lactate leakage, and
mitochondrial dysfunction. Irisin is able to significantly attenuate all of these
effects and help with reoxygenation, making it beneficial for stroke, heart attack,
and other hypoxic events.
Thus, irisin may be the reason why we dont suffocate in anaerobic exercise.
7. Is An Anti-Inflammatory And Anti-Oxidant
Irisin can attenuate inflammation of macrophages (shifting them towards a M2 state).
It can also reduce levels of IL-6, TNF-alpha, MIP-1a, and MIP-1ß.
Irisin can prevent oxidative stress in the liver (through the inhibition of protein
arginine methyltransferase-3).
Since irisin works on UCP1, it can decrease reactive oxygen species (ROS).
8. Is An Anti-Depressant
In an animal study, irisin was able to ameliorate depressive-like behaviors by
regulating energy metabolism.
9. Increases Brain Function And Motivation
Irisin increases cognitive function.
In animals, FNDC5 inhibition reduces neurogenesis, while overexpression stimulates
neural differentiation.
It can also increase brain derived neurotrophic factor (BDNF). By working on BDNF,
irisin may also work on the dopaminergic system, enhancing the motivation/reward
system.
Irisin also works on GABA and the GABAergic system.
Dysfunction of the GABAergic system may contribute to cognitive impairment in humans.
Specifically, individuals with Alzheimers Disease have decreased cerebral GABA in
the brain and CSF50. Furthermore, GABA levels in human CSF decrease with aging,
which has been associated with cognitive impairment.
The expression of irisin in the GABAergic brain cells might, to some extent, explain
its effects on the central nervous system-mediated functions.
Irisin upregulates PGC-1a. PGC1a deficient mice show a significant brain deficiency.
PGC-1a is usually under-expressed in Parkinsons Disease and Lewy body disease patient
PGC-1a by dietary treatment might benefit cognitive function and synaptic plasticity
in Alzheimers disease by preventing Aß production in the brain.
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