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Isis Unveiled, published in 1877, is a book of esoteric philosophy, and was Helena Petrovna Blavatskys first major work.

The book discusses or quotes, among others, Plato, Plotinus, the Chaldean Oracles, the Egyptian Book of the Dead, the Bible, Pythagoras, Ammonius Saccas, Porphyry, Iamblichus, Proclus, Apollonius of Tyana, the Popol Vuh, Paracelsus, Louis Jacolliot, Eliphas Levi, Marco Polo, Jesus the Nazarene, Siddhārtha Gautama, Zoroaster and Max Müller, as well as Buddhist, Brahmanical, Chinese, Persian, Babylonian, Chaldean, Syrian, Gnostic, Egyptian literature and much more.

It is composed of two volumes, the first concentrating on science, and the second on religion. The two volumes support the idea of spiritualism, and much of the content theosophizes in accordance with it. Nevertheless, Blavatsky herself distinguishes between spiritualist phenomena and Spiritualism, the religious system. She supports the verity of spiritualist phenomena as it was termed at the time, not the views of the Spiritualists as such, which she wrote about extensively in such works as The Key to Theosophy. The volume on science attempts to show how science can be just as dogmatic as religion, and betrays its own scientific method by denying spiritualism with no scientific proof against it. The volume on religion attempts to expose the hypocrisy of religion by focusing on how and where it has strayed from its origins, while simultaneously tracing the doctrines of the most revered mystics and philosophers to a common spiritual root.